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Animal wound models have confirmed that topical GHK-Cu application reduces neutrophil and macrophage infiltration by approximately 30-50% during the first 48-72 hours post-injury, while maintaining sufficient immune cell presence for bacterial clearance and debris removal
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Furthermore, the regional and temporal variations influence microbial diversity and the hosts response to disease states ( in utero to early and mid-stage adulthood, followed by a progressive collapse of healthy microbiota in late adulthood (Lahiri et al., 2009
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